郵箱: wusong@szu.edu.cn

教育經(jīng)歷：

2005.09 -- 2012.06 安徽醫(yī)科大學(xué)，臨床醫(yī)學(xué)，本碩七年制（泌尿外科學(xué)）

2012.09 -- 2015.06 中山大學(xué)，醫(yī)學(xué)博士

科研立項：

1.國家自然科學(xué)基金杰出青年科學(xué)項目：泌尿系統(tǒng)重大疾病早期信息檢測與處理（主持，項目編號：62425112，2025/01-2029/12）

2.國家自然科學(xué)基金重大研究計劃項目：膀胱癌早期演進關(guān)鍵分子事件可視化及臨床應(yīng)用（主持，項目編號：92359202，2024/01-2028/12）

3.國家自然科學(xué)基金數(shù)學(xué)天元基金：基于交互反饋和領(lǐng)域經(jīng)驗的大模型持續(xù)優(yōu)化與專病輔助診療（主持，項目編號：12326610，2024/01-2025/12）

3.科學(xué)技術(shù)部國家重點研發(fā)計劃專項：膀胱尿路上皮組織干細胞突變特征與演化研究(首席科學(xué)家，第一負責人，項目編號：2017YFA0105900，2017.7-2021.12)

4.國家自然科學(xué)基金重點項目：基于 CT 影像與尿液特征譜智能診斷膀胱癌淋巴結(jié)轉(zhuǎn)移的研究（第一負責人，項目編號：61931024，執(zhí)行時間：2020/01-2024/12）

5.國家自然科學(xué)基金優(yōu)秀青年科學(xué)項目：膀胱癌復(fù)發(fā)的分子機理研究（項目編號：81922046，2020.1-2022.12）

6.國家自然科學(xué)基金面上項目：EP400 在調(diào)控膀胱癌轉(zhuǎn)移中的功能和分子機制研究（第一負責人，項目編號：81672533，2017.1-2020.12）

7.深圳市優(yōu)秀科技創(chuàng)新人才培養(yǎng)項目（杰出青年基礎(chǔ)研究）：膀胱癌分子機理研究及早篩與診療體系構(gòu)建（項目負責人，項目編號：RCJ20200714114557005，2021.04-2026.04）

8.深圳市科技計劃項目基礎(chǔ)研究專項（重點項目）：基20220230多模態(tài)影像學(xué)診療技術(shù)模型與算法研究（項目負責人，項目編號：JCYJ20220818100015031，2022.10-2025.09）

9.深圳市戰(zhàn)略性新興產(chǎn)業(yè)發(fā)展專項資金項目：基于精準診治的膀胱癌分子分型研究及藥效評價（項目負責人，項目編號：20180309163446298，2018.7-2021.6）

10.深圳市戰(zhàn)略性新興產(chǎn)業(yè)發(fā)展專項資金（市級工程研究中心扶持計劃）：深圳市多模態(tài)融合醫(yī)學(xué)智能診斷技術(shù)工程研究中心（項目負責人，項目編號：XMHT20220104016，2021.01-2024.12）

代表性著作

1.Guoqing Lv, Qian Wang, Lin Lin, Qiao Ye, Xi Li, Qian Zhou, Xiangzhen Kong, Hongxia Deng, Fuping You, Hebing Chen, Song Wu#, Lin Yuan#. mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer. Nature Cell Biology. 2024. 7. 30, doi: 10.1038/s41556-024-01473-0

2.Songsong?Tang,Daitian?Tang, Houhong?Zhou, Yangyang?Li#, Dewang?Zhou, Xiqi?Peng, Chunyu?Ren, Yilin?Su, Shaohua?Zhang, Haoxiang?Zheng, Fangchen?Wan, Jounghyun?Yoo , Hong?Han, Xiaotian?Ma, Wei?Gao#,Song?Wu#. Bacterial outer membrane vesicle nanorobot, PNAS, 2024, 121 (30) e2403460121

3.Huancheng Yang, Hanlin Liu, Jiashan Lin, Hongwei Xiao, Yiqi Guo, Hangru Mei, Qiuxia Ding, Yangguang Yuan, Xiaohui Lai, Kai Wu, Song Wu, An automatic texture feature analysis framework of renal tumor: surgical, pathological, and molecular evaluation based on multi?phase abdominal CT, European Radiology, 2024, 34(1):355-366

4.Xiqi Peng*, Songsong Tang#, Daitian Tang, Dewang Zhou, Yangyang Li, Qiwei Chen, Fangchen Wan, Heather Lukas, Hong Han, Xueji Zhang, Wei Gao#, Song Wu#. Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy. Science Advances, 2023, 9(23):eadh1736

5.Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu; Them6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response, Cancer Research, 2023, 83(11): 1834-1850.

6.Wenqi Jiang,Mingkang Liang,Qifang Lei,Dashi Deng, Chenchen Li,Yuqing Li,Simin Yuan,Kai Wu,Guangzhi Li,Song Wu, Phenylboronic acid- functionalized chitosan for enabling transmucosal delivery for cancer therapy, Materials & Design, 2023, 229: 111843

7.Thian-Sze Wong, Guangzhi Li, Shiliang Li, Wei Gao, Geng Chen, Shiyi Gan, Manzhan Zhang, Honglin Li, Song Wu, Yang Du, G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders, Signal Transduction and Targeted Therapy, 2023, 8(1):177

8.Ting Liang, Tao Tao, Kai Wu, Lisha Liu, Wuwu Xu, Dewang Zhou, Hu Fang, Qiuxia Ding, Guixiao Huang, Song Wu, Cancer-Associated Fibroblast-Induced Remodeling of Tumor Microenvironment in Recurrent Bladder Cancer, Advanced Science, 2023, 10(31):e2303230

9.Huancheng Yang, Jiashan Lin, Hanlin Liu, Jiehua Yao, Qianyu Lin, Jiaxin Wang, Feiye Jiang, Liying Wei, Chongyang Lin, Kai Wu, Song Wu, Automatic analysis framework based on 3D?CT multi?scale features for accurate prediction of Ki67 expression levels in substantial renal cell carcinoma, Insights into Imaging, 2023, 14(1):130.

10.Huancheng Yang, Kai Wu, Hanlin Liu, Peng Wu, Yangguang Yuan, Lei Wang, Yaru Liu, Haoyang Zeng, Junkai Li, Weihao Liu, Song Wu, An automated surgical decision?making framework for partial or radical nephrectomy based on 3D?CT multi?level anatomical features in renal cell carcinoma, European Radiology, 2023, 33(11):7532-7541

11.Guangzhi Li; Tao Tao; Dashi Deng; Shaohua Zhang; Yu Chao; Yizhi Dai; Yuqing Li; Ran Tao; Simin Yuan; Zhuang Liu; Song Wu ; Collagen-targeted tumor-specific transepithelial penetration en hancer mediated intravesical chemoimmunotherapy for non-muscle-invasive bladder cancer, Biomaterials, 2022, 283:121422

12.Wu Kai; Wu Peng; Yang Kai; Li Zhe; Kong Sijia; Yu Lu; Zhang Enpu; Liu Hanlin; Guo Qing; Wu Song ; A comprehensive texture feature analysis framework of renal cell carcinoma: pathological, prognostic, and genomic evaluation based on CT images, European Radiology, 2022, 32(4):2255-2265

13.Cong Z, Tang S, Xie L, Yang M, Li Y, Lu D, Li J, Yang Q, Chen Q, Zhang Z, Zhang X, Wu S. Magnetic-Powered Janus Cell Robots Loaded with Oncolytic Adenovirus for Active and Targeted Virotherapy of Bladder Cancer. Adv Mater. 2022 Jul;34(26):e2201042.

14.Li Yangyang, Tang Songsong, Cong Zhaoqing, Lu Dongdong, Yang Qingxin, Chen Qiwei, Zhang Xueji, Wu Song, Biohybrid bacterial microswimmers with metal-organic framework exoskeletons enable cytoprotection and active drug delivery in a harsh environment. Mater. Today Chem., 2022, 23: 100609.

15.Dongdong Tang, Yangyang Li, Ying Tang, Haoxiang Zheng, Weihan Luo, Yuqing Li, Yingrui Li, Zhiping Wang, Song Wu, Recognition of Glycometabolism-Associated lncRNAs as Prognosis Markers for Bladder Cancer by an Innovative Prediction Model, Frontiers in Genetics, 2022, 13:918705

16.Chenfan Kong, Shaohua Zhang, Qifang Lei, Song Wu, State-of-the-Art Advances of Nanomedicine for Diagnosis and Treatment of Bladder Cancer, Biosensors, 2022, 12(10):796

17.Yongpeng Li, Yanan Tan, Lijuan Wen, Zhihao Xing, Changxu Wang, Liuhui Zhang, Kai Wu, Haiyan Sun, Yuqing Li, Qifang Lei, Song Wu, Overexpression of BIRC6 driven by EGF-JNK-HECTD1 signaling is a potential therapeutic target for triple-negative breast cancer, Molecular Therapy: Nucleic Acids, 2021,26(3), 798-812

18.Qiwei Chen, Songsong Tang, Yangyang Li, Zhaoqing Cong, Dongdong Lu, Qingxin Yang, Xueji Zhang, and Song Wu；Multifunctional Metal-Organic Framework Exoskeletons Protect Biohybrid Sperm Microrobots for Active Drug Delivery within Surrounding Threats, ACS Applied Materials & Interfaces, 2021 13 (49), 58382-58392

19.Qin Junjie; Shi Xulian; Xu Junming; Yuan Simin; Zheng Bo; Zhang Enpu; Huang Guixiao; Li G uo; Jiang Ganggang; Gao Shan; Tian Cheng; Guo Ruochun; Fu Zhicong; Huang Qingru; Yang Rentao; Zha ng Wenyong; Li Shenghui; Wu Song ; Characterization of the Genitourinary Microbiome of 1,165 Midd le-Aged and Elderly Healthy Individuals, Frontiers in Microbiology, 2021, 12: 673969

20.Zhang Shaohua; Li Guangzhi; Deng Dashi; Dai Yizhi; Liu Zhuang; Wu Song ; Fluorinated Chit osan Mediated Synthesis of Copper Selenide Nanoparticles with Enhanced Penetration for Second Nea r-Infrared Photothermal Therapy of Bladder Cancer, Advanced Therapeutics, 2021, 4(7): 2100043

21.Chen Sujun; Zhu Guanghui; Yang Yue; Wang Fubo; Xiao Yu-Tian; Zhang Na; Bian Xiaojie; Zhu Yasheng; Yu Yongwei; Liu Fei; Dong Keqin; Mariscal Javier; Liu Yin; Soares Fraser; Loo Yau Helen; Zhang Bo; Chen Weidong; Wang Chao; Chen Dai; Guo Qinghua; Yi Zhengfang; Liu Mingyao; Fraser Micha el; De Carvalho Daniel D.; Boutros Paul C.; Di Vizio Dolores; Jiang Zhou; van der Kwast Theodorus; Berlin Alejandro; Wu Song; Wang Jianhua; He Housheng Hansen; Ren Shancheng ; Single-cell analys is reveals transcriptomic remodellings in distinct cell types that contribute to human prostate c ancer progression, Nature Cell Biology, 2021, 23(1): 87-98

22.Li Jing; Xu Chuanliang; Lee Hyung Joo; Ren Shancheng; Zi Xiaoyuan; Zhang Zhiming; Wang Ha ifeng; Yu Yongwei; Yang Chenghua; Gao Xiaofeng; Hou Jianguo; Wang Linhui; Yang Bo; Yang Qing; Ye Huamao; Zhou Tie; Lu Xin; Wang Yan; Qu Min; Yang Qingsong; Zhang Wenhui; Shah Nakul M.; Pehrsson Erica C.; Wang Shuo; Wang Zengjun; Jiang Jun; Zhu Yan; Chen Rui; Chen Huan; Zhu Feng; Lian Bijun; Li Xiaoyun; Zhang Yun; Wang Chao; Wang Yue; Xiao Guangan; Jiang Junfeng; Yang Yue; Liang Chaozhao; Hou Jianquan; Han Conghui; Chen Ming; Jiang Ning; Zhang Dahong; Wu Song; Yang Jinjian; Wang Tao; Chen Yongliang; Cai Jiantong; Yang Wenzeng; Xu Jun; Wang Shaogang; Gao Xu; Wang Ting; Sun Yingh ao ; A genomic and epigenomic atlas of prostate cancer in Asian populations, Nature, 2020, 580(78 01): 93-99

23.Sun Rui; Liu Xiaocen; Li Guangzhi; Wang Hui; Luo Yongxiang; Huang Guixiao; Wang Xisheng; Zeng Guohua ; Liu Zhuang; Wu Song ; Photoactivated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer, ACS Nano, 2020, 14(7): 8135-8148

24.Wu Song; Ou Tong; Xing Nianzeng; Lu Jiang; Wan Shengqing; Wang Changxi; Zhang Xi; Yang Fe iya; Huang Yi; Cai Zhiming ; Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer, Nature communications, 2019, 10 (1): 1-12

25.Li Guangzhi; Lei Qifang; Wang Fei; Deng Dashi; Wang Shupeng; Tian Longlong; Shen Wanwan; Cheng Yiyun; Liu Zhuang; Wu Song ; Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer, Small, 2019, 15(25): e1900936

26. Li Guangzhi; Yuan Simin; Deng Dashi; Ou Tong; Li Yuqing; Sun Rui; Lei Qifang; Wang Xishen g; Shen Wanwan; Cheng Yiyun; Liu Zhuang; Wu Song ; Fluorinated Polyethylenimine to Enable Transmu cosal Delivery of Photosensitizer-Conjugated Catalase for Photodynamic Therapy of Orthotopic Blad der Tumors Postintravesical Instillation, Advanced Functional Materials, 2019, 29(40):1901932

27.Huang Yi; Wang Jiayin; Jia Peilin; Li Xiangchun; Pei Guangsheng; Wang Changxi; Fang Xiaod ong; Zhao Zhongming; Cai Zhiming; Yi Xin; Wu Song; Zhang Baifeng ; Clonal architectures predict clinical outcome in clear cell renal cell carcinoma, Nature Communications, 2019, 10(1): 1245

28.Shuai Wang; Peng Wu; Manqi Zhou; Tsung-Hui Chang; Song Wu ; Cell Subclass Identification in Single-Cell RNA-Sequencing Data Using Orthogonal Nonnegative Matrix Factorization, 2018 IEEE I nternational Conference on Acoustics, Speech And Signal Processing (ICASSP), Calgary, AB, Canada, 2018-04-15至2018-04-20

29.Yang Zhao; Li Chong; Liu Hongjie; Zhang Xiaolong; Cai Zhiming; Xu Liqin; Luo Jian; Huang Yi; He Luyun; Liu Chunxiao; Wu Song ; Single-cell sequencing reveals variants in ARID1A, GPRC5A a nd MLL2 driving self-renewal of human bladder cancer stem cells, European Urology, 2017.1, 71(1): 8-12

30.Wu Song; Huang Peide; Li Chong; Huang Yi; Li Xianxin; Wang Yongqiang; Chen Chao; Lv Zhaoj ie; Tang Aifa; Sun Xiaojuan; Lu Jingxiao; Li Weiping; Zhou Jie; Gui Yaoting; Zhou Fangjian; Wang Daping; Cai Zhiming ; Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the O rigin of Urogenital Tumors: A Genomic and Molecular Study, European Urology, 2014.2, 65(2): 274-277

31.Guo Guangwu; Sun Xiaojuan; Chen Chao; Wu Song; Huang Peide; Li Zesong; Dean Michael; Hua ng Yi; Jia Wenlong; Zhou Quan; Tang Aifa; Yang Zuoquan; Li Xianxin; Song Pengfei; Zhao Xiaokun; Ye Rui; Zhang Shiqiang; Lin Zhao; Qi Mingfu; Wan Shengqing; Xie Liangfu; Fan Fan; Nickerson Michae l L.; Zou Xiangjun; Hu Xueda; Xing Li; Lv Zhaojie; Mei Hongbin; Gao Shengjie; Liang Chaozhao; Gao Zhibo; Lu Jingxiao; Yu Yuan; Liu Chunxiao; Li Lin; Fang Xiaodong; Jiang Zhimao; Yang Jie; Li Cail ing; Zhao Xin; Chen Jing; Zhang Fang; Lai Yongqi; Lin Zheguang; Zhou Fangjian; Chen Hao; Chan Hsi ao Chang; Tsang Shirley; Theodorescu Dan; Li Yingrui; Zhang Xiuqing; Wang Jian; Yang Huanming; Gu i Yaoting; Wang Jun; Cai Zhiming ; Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation, Nature Genetics, 2013, 45(12): 1459-U213